Stanford Study

The manufacture of NAC requires minimization of NAC oxidation to its dimeric form (‘di-NAC’), which is pharmacologically active at very low concentrations with immunologic effects opposite to those of NAC. In general, di-NAC constitutes less than 0.1% of NAC produced according to European GMP standards. Several US nutriceutical dealers manufacture and sell NAC alone or in combination with other daily supplements such as vitamins and antioxidants. However, since the FDA does not regulate the production and packaging of nutriceutical products in the US, neither the content nor the purity of the NAC formulations currently produced and marketed in the US can be reliably judged. It is important to note that manufacturing methods for these NAC preparations may not include measures to prevent oxidation of NAC to its dimeric form either during manufacture or while the product is stored. End of quote.

This means that exposure to air during processing causes the NAC to degrade and destabilize, not only reducing effectiveness, but possibly degrading into higher concentrations of di-NAC. The Germans adhere to the GMP standards, using minimal air exposure during processing, and then sealing each dose individually in air tight material, providing you with the powerful benefits of the purest oral dose of NAC available.



	Excerpt from Stanford Study Herzenberg, Atkuri KR, et al., N-Acetylcysteine—a safe antidote for cysteine/glutathione deficiency, Curr Opin Pharmacol (2007), doi:10.1016/j.coph.2007.04.005 The manufacture of NAC requires minimization of NAC oxidation to its dimeric form (‘di-NAC’), which is pharmacologically active at very low concentrations with immunologic effects opposite to those of NAC. In general, di-NAC constitutes less than 0.1% of NAC produced according to European GMP standards. Several US nutriceutical dealers manufacture and sell NAC alone or in combination with other daily supplements such as vitamins and antioxidants. However, since the FDA does not regulate the production and packaging of nutriceutical products in the US, neither the content nor the purity of the NAC formulations currently produced and marketed in the US can be reliably judged. It is important to note that manufacturing methods for these NAC preparations may not include measures to prevent oxidation of NAC to its dimeric form either during manufacture or while the product is stored. End of quote. This means that exposure to air during processing causes the NAC to degrade and destabilize, not only reducing effectiveness, but possibly degrading into higher concentrations of di-NAC. The Germans adhere to the GMP standards, using minimal air exposure during processing, and then sealing each dose individually in air tight material, providing you with the powerful benefits of the purest oral dose of NAC available.

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